Profile

C. Shekhar Mayanil, PhD
Director of Developmental Neurobiology Research in Pediatric Neurosurgery

smayanil@northwestern.edu; cmayanil@luriechildrens.org 

Education 

 Year 

 Degree 

Institution 

1984

Ph.D.

Jawaharlal Nehru University, New Delhi, India

Research Interests 

1. Neural crest stem cells and the Gene Regulatory Network
2. Neurogenesis permissive chromatin during caudal neural tube development
3. Mechanisms of epigenetic rescue of neural tube closure defects by folic acid
4. Discovery and validation of epigenetic markers for Spina Bifida

Recent Publications 

Ichi S, Boshnjaku V, Shen YW, Mania-Farnell B, Ahlgren S, Sapru S, Mansukhani N, McLone DG, Tomita T, Mayanil CS. Role of Pax3 acetylation in the regulation of Hes1 and Neurog2. Mol Biol Cell 2011 Feb;22(4):503-12.

Ichi S, Costa FF, Bischof JM, Nakazaki H, Shen YW, Boshnjaku V, Sharma S, Mania-Farnell B, McLone DG, Tomita T, Soares MB, Mayanil CS. Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development. J Biol Chem 2010 Nov 19;285(47):36922-32.

Nakazaki, H., Shen, Y-W., Yun, B., Reddy, A. C., Khanna, V., Ichi, S., Mania-Farnell, B., McLone, D. G. and Tomita, T. and Mayanil, C. S. (2009) Transcriptional Regulation by Pax3 and TGFβ2 signaling constitute a gene regulatory network. Int. J. Dev. Biol. 53: 69-79.

Nakazaki H., Reddy, A. C., Mania-Farnell B., McCabe, C., Ichi, S., George, D., McLone D. G., Tomita T. and Mayanil, C. S. (2008) Key basic helix loop helix transcription factor genes Hes1 and Ngn2 are regulated by Pax3 during mouse embryonic development. Dev. Biol. 316: 510-523.

Mayanil, C. S., Pool, A., Nakazaki, H., Reddy, A., Mania-Farnell, B., Yun, B., George, D., McLone, D. G., and Bremer, E. G. (2006) Regulation of murine TGFβ2 by Pax3 during early embryonic development. J. Biol. Chem. 281: 24544-24552.

Mayanil, C.S., George, D., Freilich, L., Miljan, E.J., Mania-Farnell, B., McLone, D.G. and Bremer, E.G. (2001) Microarray Analysis Detects Novel Pax3 Downstream Target Genes. J. Biol. Chem. 276, 49299-49309.

Mayanil, C.S., George, D., Mania-Farnell, B., Bremer, C., McLone, D. G. and Bremer, E. G. (2000) Over-expression of murine Pax3 increases NCAM polysialylation in a human medulloblastoma cell line. J. Biol. Chem. 275: 23259-23266.

In the First World Congress on Spina Bifida Research and Care in Orlando (March 15-18, 2009) was awarded 2nd prize for Most Significant Original Research Contribution for the paper entitled, "Implication of bivalent chromatin and microRNA as potential folic acid responsive targets in folate-mediated rescue of neural tube defects in mouse model of Spina Bifida".

Curriculum Vitae 

 View Shekhar Mayanil's CV.