Oncology

For information on the following Clinical Trials, please contact the
Hematology, Oncology and Stem Cell Transplantation Department
at 312-227-4090 during 8:30 AM to 5:00 PM Central Standard Time.

 

Short Title Acute Lymphoblastic Leukemia (ALL):

Investigator

100EUSA12 An Open Label, Single Arm, Multi-Center Pharmacokinetic Study of Intravenous Erwinaze, following allergy to Native E. Coli Asparaginase or Pegaspargase, or Calaspargase pegol. Nobuko Hijiya, MD
AALL0434 Intensified Methotrexate, Nelarabine (Compound 506u78; IND#52611) and Augmented BFM Therapy for Children and Young Adults with Newly Diagnosed T-cell Acute Lymphoblastic Leukemia  Elaine Morgan, MD 
AALL05B1  A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens

Elaine Morgan, MD

AALL0631 A Phase III Study of Risk Directed Therapy for Infants with Acute Lymphoblastic Leukemia (ALL): Randomization of Highest Risk Infants to Intensive Chemotherapy +/- FLT3 Inhibition (CEP-701, Lestaurtinib; IND#76431; NSC#617807)

Elaine Morgan, MD

AALL08B1 AALL08B1 Classification of Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) Elaine Morgan, MD
AALL0932        Treatment of Patients with Newly Diagnosed Standard Risk B-Precursor Acute Lymphoblastic Leukemia (ALL) Elaine Morgan, MD
AALL1122 A Phase II Multi-Center, Historically-Controlled Study of Dasatinib added to standard chemotherapy in pediatric patients with newly diagnosed Philidelphia Chromosome Positive (PH+) Acute Lymphoblastic Leukemia (ALL). Nobuko Hijiya, MD
AALL1131     A Phase III Randomized Trial for newly diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia testing Clofarabine in the very high risk stratum Elaine Morgan, MD
ACCL1033 A Comprehensive Approach to improve medicatio adherence in pediatric ALL Elaine Morgan, MD
CA180226 Phase II Study of Dasatinib Therapy for CML or PH+ Nobuko Hijiya, MD
CAMN107A21 A Mulit-Center, Open-Label, Pharmacokinetic Study of Oral Nilotinib in Pediatric Patients with Gleeved (Imatinib)-Resistant/Intolerant Ph+ CML Chronic Phase (CP) or Accelerated Phase (AP) or With Refractory/Relapsed Ph+ ALL Nobuko Hijiya, MD
DFCI 11-23 A Feasibility trial of Everolimus (RAD001), an mTOR inhibitor, given in combination with multiagent re-induction chemotherapy in pediatric patients with relapsed Acute Lymphoblastic Leukemia (ALL) Nobuko Hijiya, MD
Extra BM Extra Bone Marrow Collection Elaine Morgan, MD
T2008-002 A Phase I Trial of NECTAR (Nelarabine, Etoposide and Cyclophosphamide in T-ALL Relapse) A Joint Study of TACL and POETIC Nobuko Hijiya, MD
T2009-008 A Phase I study of GNKG168 in pediatric patients with Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia Nobuko Hijiya, MD
T2009-012 A Phase I dose finding study of Panobinostat in children with Refractory Hematologic Malignancies Nobuko Hijiya, MD
CC1406 Prediction of Delayed Excretion & Toxicity of High Dose Methotrexate in Children & Adolescents with ALL. Amy Walz, MD
     
Short Title Acute Myeloid Leukemia (AML): Investigator
AAML08B1 Biology Study of Transient Myeloproliferative Disorder (TMD) in Children with Down Syndrome (DS) Elaine Morgan, MD
AAML1031     A Phase III Randomized Trial for Patients with de novo AML Using Bortezomib (IND# 58443, NSC #681239) and Sorafenib (BAY 43-9006, IND#69896, NSC# 724772) for Patients with High Allelic Ratio FLT3/ITD Nobuko Hijiya, MD
ACCL0933 A Randomized Open-Label Trial of Caspofungin versus Fluconazole to Prevent Invasive Fungal Infections in Children Undergoing Chemotherapy for Acute Myeloid Leukemia (AML) David Walterhouse, MD
CPKC412A21 A Phase I/II, Open-Label, Dose-Escalating Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Twice Daily Oral Midostaurin and to Evaluate the Preliminary Clinical and Pharmacodynamic Response in Pediatric Patients with Relapse. Nobuko Hijiya, MD
     
Short Title ALCL/NHL Lymphoma Investigator
ANHL1131 Intergroup Trial for Children or Adolescents with B-Cell Non-Hodgkin Lymphoma NHL or Mature B-Cell Leukemia B- AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients Joanna Weinstein, MD
     
Short Title Developmental Therapeutics: Investigator
ADVL0912 A Phase I/II Study of PF-02341066, an Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-MET, in Children with Relapsed / Refractory Solid Tumors and Anaplastic Large Cell Lymphoma Stewart Goldman, MD
ADVL1011 A Phase I Dose Escalation Study of Seneca Valley Virus (NTX-010), A Replication-Competent Picornavirus, in Relapsed/Refractory Pediatric Patients with Neuroblastoma, Rhabdomyosarcoma, Rare Tumors with Neuroendocrine  Features Stewart Goldman, MD
ADVL1111 A Phase 1 Study of the c-Met Inhibitor ARQ 197 (Tivantinib) in Children with Relapsed or Refractory Solid Tumors Stewart Goldman, MD
ADVL1114 A Phase I Study of Temsirolimus (CCI-779, IND#61010) in Combination with Intensive Re-Induction Therapy for Children with Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma Stewart Goldman, MD
ADVL1211 A Phase 1 Study of XL184 (Cabozantinib, IND#116059) in Children and Adolescents with Recurrent or Refractory Solid Tumors, Including CNS Tumors Stewart Goldman, MD
ADVL1212     A Phase I Study of Crizotinib (IND# 105573) in Combination with Conventional Chemotherapy for Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Stewart Goldman, MD
ADVL1213 A Phase I Study of the TEM-1 antibody, MORAb-004 (IND# 103821), in Children with Recurrent or Refractory Solid Tumors Stewart Goldman, MD
ADVL1217 A Phase I Study of MK-1775 (IND#116459) Concurrent with Local Radiation Therapy for the Treatment of Newly Diagnosed Children with Diffuse Intrinsic Pontine Gliomas Stewart Goldman, MD
     
Short Title Ewings Sarcoma: Investigator
AEWS02B1 A Groupwide Biology and Banking Study for Ewing Sarcoma David Walterhouse, MD
AEWS07B1 A COG Study for Collecting and Banking Ewing Sarcoma Specimens David Walterhouse, MD
AEWS1031    A Phase III Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma David Walterhouse, MD
     
Short Title Hepatoblastoma (HEP): Investigator
AHEP0731 Treatment of Children with All Stages of Hepatoblastoma:A Groupwide Phase III Study Yasmin Gosiengfiao, MD
     
Short Title Hodgkins (HOD): Investigator
AHOD04B1 Hodgkin Disease Banking Study Joanna Weinstein, MD
     
Short Title Late Effects: Investigator
ALTE03N1 Key Adverse Events after Childhood Cancer  Reggie Duerst, MD
ALTE05N1 Umbrella Long-Term Follw-up Protocol Jennifer Reichek, MD
ALTE07C1 Neuropsychological Testing Stewart Goldman, MD
     
Short Title Miscellaneous: Investigator
Continued Participation Continued Participation in COG Research David Walterhouse, MD
ACCRN07 Protocol for the Enrollment on the Official COG Registry, The Childhood Cancer Research Network (CCRN) David Walterhouse, MD
     
Short Title Neuroblastoma (NBL): Investigator

ANBL0032    
   

Phase III Randomized Study of Chimeric Antibody 14.18 in High Risk NBL following Myeloablative Therapy and Autologous Stem Cell Rescue

 

Yasmin Gosiengfiao, MD
ANBL00B1 Neuroblastoma Biology Studies Yasmin Gosiengfiao, MD
ANBL1221 A Phase II Randomized Trial of Irinotecan/Temozolomide with Temsirolimus or Chimeric Antibody in Children with Refractory, Relapsed or Progressive Neuroblastomas Yasmin Gosiengfiao, MD
ANBL12P1 Pilot Study Using Myeloablative Busulfan/Melphalan Consolidation Following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastomas Yasmin Gosiengfiao, MD
     
Short Title Osteosarcoma (OST): Investigator
AOST06B1 A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens David Walterhouse, MD
     
Short Title Rare Tumors (RAR): Investigator
ABTR01B1   
A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors Yasmin Gosiengfiao, MD
     
Short Title Renal (REN): Investigator
9442 National Wilms' Tumor Late Effects Study Morris Kletzel, MD
AREN03B2 Renal Tumors Classification, Biology and Banking Study Yasmin Gosiengfiao, MD
AREN0534 Treatment for Patients with Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor Yasmin Gosiengfiao, MD
     
Short Title Retinoblastoma (RET):  Investigator

ARET0321

A Trial of Intensive Milti-Modality Therapy for Extra-Ocular Retinoblastoma Joanna Weinstein, MD
     
Short Title Rhabdomyosarcoma (RST): Investigator
D9902  A Group-Wide Protocol for Collecting and Banking Pediatric Cancer Research Specimens. An Intergroup Rhabdomyosarcoma Study Group Protocol David Walterhouse, MD
     
Short Title Fertility Investigator
CMH11CC08 Pilot Study of the Effects of Cancer Treatment on Testicular Reserve Yasmin Gosiengfiao, MD
ORACLE Ovarian Reserve after Cancer: Longitudinal Effects Yasmin Gosiengfiao, MD
Ov. Cryopr Ovarian Tissue Freezing Prior to Chemotherapy or Radiation Therapy Yasmin Gosiengfiao, MD
PP OTC Pre-Pubertal Ovarian Tissue Cryopreservation Yasmin Gosiengfiao, MD