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Topczewski Laboratory
The Topczewski laboratory investigates the mechanisms that control the morphogenetic processes of vertebrate embryos, by using zebrafish as a model. Similarities in developmental programs among all vertebrates make zebrafish an excellent model for studying human diseases and development. In our work we utilize a combination of genetic analysis with embryological and molecular methods uniquely available in zebrafish. Our long-term goal is the identification of signaling pathways that will suggest novel candidate genes involved in human congenital abnormalities and diseases.
Recent Publications
Flowers GP, Topczewska JM, Topczewski J (2012) A zebrafish Notum homolog specifically blocks the Wnt/β-catenin signaling pathway.Development 139:2416-25.
Moore A, Mark T, Hogan A, Topczewski J, Leclair EE. Peripheral axons of the adult zebrafish maxillary barbel extensively remyelinate during sensory appendage regeneration. J Comp Neurol. May 17. doi: 10.1002/cne.23147. [Epub ahead of print]
Topczewski J Dale, R.M., Sisson, B.E (2011) Planar cell polarity in the craniofacial development. Organogenesis 7:255-259
Biyashev D, Veliceasa D, Topczewski J, Topczewska JM, Mizgirev I, Alagarsamy L, Licht JL, Revskoy SY, and Volpert OV. (2012) MiR-27b controls tip cell fate and venous specification of the endothelial cells. Blood 15;119(11):2679-87Dale RM, Topczewski J. (June 2011) Identification of an evolutionarily conserved regulatory element of the zebrafish col2a1a gene. Dev Bio 357;518-531
Duszynski RJ, Topczewski J, LeClair EE. (2011) Simple, Economical
Heat-Shock Devices for Zebrafish Housing Racks. Zebrafish 8:211-219
Sarmah S, Barrallo-Gimeno A, Melville DB, Topczewski J, Solnica-Krezel L, Knapik EW. (2010) Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis. PLoS One. 28;5:e10367.
LeClair EE, Topczewski J, (2010) Development and Regeneration of the Zebrafish Maxillary Barbel: A Novel Study System for Vertebrate Tissue Growth and Repair. PLoS ONE 5: e8737.
Camarata T, Krcmery J, Snyder D, Park S, Topczewski J, Simon H-G (2010). Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation. Dev Biol 15;337:233-345. Epub 2009 Nov 3
LeClair EE, Topczewski J (2009) Methods for the study of the zebrafish maxillary barbel. JoVE 23;(33). pii: 1558.
Topczewski J and Solnica-Krezel L. (2009). Cytoskeletal dynamics of the zebrafish embryo. Essential zebrafish methods: Cell and developmental biology. Reliable Lab Solutions Series. Elsevier Inc. pp 133-157
LeClair EE, Mui S, Huang A, Topczewska JM, Topczewski J (2009) Craniofacial skeletal defects of adult zebrafish glypican 4 (knypek) mutants. Dev Dynamics 238(10):2550-2563
Sisson BE and Topczewski J (2009). Expression of five frizzleds during zebrafish craniofacial development. GEP: 520-7
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